Freeze-dried B.C.G. Vaccine

The Present Position of Freeze-Dried BCG Vaccine

I reviewed in 1952 the literature on freeze-dried BCG vaccine in order to help evaluate the relative merits of fresh liquid and dried vaccines on the basis of the results of vaccination. More BCG production centres have since taken to the preparation of dried BCG vaccine for either experimental use or for vaccination. In India, the scene of activity of the mass vaccination campaign has shifted ...

Determination of the Viability at +4°C of Freeze-Dried Attenuated Live Agalactiae Vaccine

Freeze-dried B.C.G.

Freeze-dried B.C.G. of British manufacture became available for experimental work in 1955. The main reason for introducing it was the need for a vaccine which would retain its potency under conditions of prolonged storage. On reconstitution for injection the vaccine should produce a uniform suspension with minimal clumping, resulting in a uniform viable bacterial count. These properties mean th...

BCG vaccine and pulmonary tuberculosis

Tuberculosis (TB) is one of the most important public health problems in the world and has been declared as a global emergency by the World Health Organization (WHO) in 1993. Bacillus Calmette-Guérin (BCG) is one of the first developed vaccines to prevent TB. Unfortunately, BCG vaccine has had a limited duration of protection and has shown controversial and variable levels of efficacy, especial...

change of BCG vaccine

BCG vaccines are the oldest vaccines in use today, but the protective effect of the vaccination is still controversial. The risk of contracting tuberculosis is low compared with the possible complications after this vaccination. In Austria the formerly used BCG vaccine was not available in the required amount and another vaccine was released by the drug authorities. This product, with a more vi...